Best Price Right Now
Best moneyline: Arizona Cardinals +365 at BetRivers (runner-up +365 at Bally Bet); San Francisco 49ers -373 at Pinnacle (runner-up -429 at ReBet).
Spread: San Francisco 49ers -8.5 (consensus). Best price: Arizona Cardinals +8.5 (-110) at DraftKings (runner-up -110 at Caesars); San Francisco 49ers -8.5 (-102) at Pinnacle (runner-up -105 at FanDuel).
Total (over/under): 47.5 (consensus). Best price: Over 47.5 (-110) at MyBookie.ag (runner-up -113 at BetRivers); Under 47.5 (+102) at Pinnacle (runner-up +100 at 888sport).
Compared across 17 sportsbooks as of September 21, 2026 at 2:00 AM UTC. The best book often differs by market and by side — the full board is below.
Line Movement
Since Sep 20, 8 PM ET, the moneyline has moved toward Arizona Cardinals (San Francisco 49ers price improved from -455 to -373).
| Market | Tracking opened (Sep 20, 8 PM ET) | Now |
|---|---|---|
| Moneyline (best available) | Arizona Cardinals +385 / San Francisco 49ers -455 | Arizona Cardinals +365 / San Francisco 49ers -373 |
| Spread (San Francisco 49ers, consensus) | -8.5 | -8.5 |
| Total (consensus) | 47.5 | 47.5 |
Full Odds Board
| Sportsbook | Arizona Cardinals | San Francisco 49ers | Spread (San Francisco 49ers) | Total | O / U |
|---|---|---|---|---|---|
| DraftKings | +350 | -455 | -8.5 (-110) | 48.5 | -105 / -115 |
| Caesars | +350 | -460 | -8.5 (-110) | 47.5 | -118 / -103 |
| BetUS | — | — | -9 (-110) | 48 | -110 / -110 |
| FanDuel | +360 | -460 | -8.5 (-105) | 47.5 | -115 / -105 |
| ReBet | +320 | -429 | -8.5 (-110) | 47.5 | -120 / -109 |
| BetRivers | +365 | -500 | -8.5 (-108) | 47.5 | -113 / -108 |
| Bally Bet | +365 | -500 | -8.5 (-108) | 47.5 | -113 / -108 |
| betPARX | +365 | -500 | -8.5 (-108) | 47.5 | -113 / -108 |
| LowVig.ag | — | — | -9 (-105) | 48 | -107 / -107 |
| BetOnline.ag | — | — | -9 (-110) | 48 | -110 / -110 |
| 888sport | +320 | -450 | -8.5 (-110) | 47.5 | -125 / +100 |
| MyBookie.ag | +310 | -450 | -8.5 (-110) | 47.5 | -110 / -110 |
| Fliff | +340 | -500 | -8.5 (-115) | 47.5 | -115 / -110 |
| BetMGM | +340 | -450 | -8.5 (-108) | 48 | -108 / -110 |
| Hard Rock Bet | +350 | -450 | -8 (-115) | 47.5 | -115 / -105 |
| Pinnacle | +304 | -373 | -8.5 (-102) | 47.5 | -116 / +102 |
| theScore Bet | +360 | -500 | -8 (-115) | 47.5 | -115 / -105 |
Pricing Context: NFL Vig
Lowest-vig sportsbooks for NFL right now: LowVig.ag (A, 2.96% avg vig), Pinnacle (B+, 3.16% avg vig), BetMGM (B, 4.33% avg vig). Lower vig means the book keeps less of every dollar wagered — the best single-game price and the best long-run pricing are not always the same book. Pinnacle, which holds a best price on this game, grades B+ on NFL vig overall.
Frequently Asked Questions
Which sportsbook has the best odds for Arizona Cardinals vs San Francisco 49ers?
Best available moneyline right now: Arizona Cardinals +365 at BetRivers (runner-up +365 at Bally Bet); San Francisco 49ers -373 at Pinnacle (runner-up -429 at ReBet). Prices refresh hourly — the full board below shows every tracked sportsbook.
What is the spread for Arizona Cardinals vs San Francisco 49ers?
The consensus spread is San Francisco 49ers -8.5. Best price at that number: Arizona Cardinals +8.5 (-110) at DraftKings (runner-up -110 at Caesars); San Francisco 49ers -8.5 (-102) at Pinnacle (runner-up -105 at FanDuel). Some sportsbooks deal a different number — the full board below lists every book's spread.
What is the over/under for Arizona Cardinals vs San Francisco 49ers?
The consensus total is 47.5. Best price at that number: Over 47.5 (-110) at MyBookie.ag (runner-up -113 at BetRivers); Under 47.5 (+102) at Pinnacle (runner-up +100 at 888sport).
Has the line moved for Arizona Cardinals vs San Francisco 49ers?
Since Sep 20, 8 PM ET, the moneyline has moved toward Arizona Cardinals (San Francisco 49ers price improved from -455 to -373).
How current are these odds?
Odds are refreshed hourly from live sportsbook data (last update: September 21, 2026 at 2:00 AM UTC). Odds change quickly around game time — always verify the price at the book before betting.
How We Calculate These Numbers
- Data Source
- All odds on this page come from The Odds API, which aggregates real-time lines from licensed US and offshore sportsbooks. We track moneyline, spread, and totals markets across every sport with active betting lines.
- Update Frequency
- We pull a fresh snapshot of every tracked market every hour, on the hour (UTC). Each snapshot captures the latest lines from every sportsbook that has posted odds for a given event. The timestamp at the top of each page tells you exactly when the data was last refreshed.
- Vig Calculation
- Vig (short for vigorish, also called juice or overround) measures the margin a sportsbook builds into its odds. We calculate it by converting the odds on each side of a market to implied probabilities, summing those probabilities, and subtracting 100%. For example, a market priced at -110/-110 implies 52.38% on each side — a total of 104.76%, meaning a vig of 4.76%. Lower vig means better value for bettors because you keep more of your winnings.
- Per-Market Breakdown
- We compute vig separately for each market type: moneyline (h2h), point spreads, and totals (over/under). The "average vig" shown for each sportsbook is the mean across all market types weighted by the number of events sampled in each market.
- Grading Scale
- Every sportsbook receives a letter grade based on its average vig: A+ (under 2%) is exchange-level pricing. A (2–3%) is very competitive. B+ (3–4%) is above average. B (4–5%) is the industry standard — a -110/-110 line is 4.76%. C+ (5–6%) is slightly below average. C (6–7%) is below average. D (7–8%) is high vig. D− (8–10%) is very high vig. F (10%+) is predatory pricing. See the full Vig Index Methodology for formulas, worked examples, and known limitations.
- Trend Tracking
- We store daily snapshots for 30 days, allowing us to show 24-hour and 7-day vig trends. A downward trend (improving) means sportsbooks are tightening their lines — often in response to increased competition or higher betting volume as a season heats up.